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Generalist genes and cognitive neuroscience.

Butcher LM, Kennedy JK, Plomin R

Social, Genetic and Developmental Psychiatry Centre, Number P080, Institute of Psychiatry, DeCrespigny Park, London, SE5 8AF, United Kingdom.

Multivariate genetic research suggests that a single set of genes affects most cognitive abilities and disabilities. This finding already has far-reaching implications for cognitive neuroscience, and will become even more revealing when this - presumably large - set of generalist genes is identified. Similar to other complex disorders and dimensions, molecular genetic research on cognitive abilities and disabilities is adopting genome-wide association strategies. These strategies involve very large samples to detect DNA associations of small effect size using microarrays that simultaneously assess hundreds of thousands of DNA markers. When this set of generalist genes is identified, it can be used to provide solid footholds in the climb towards a systems-level understanding of how genetically driven brain processes work together to affect diverse cognitive abilities and disabilities.

Published 17 April 2006 in Curr Opin Neurobiol, 16(2): 145-51.
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